The A-77636 topic is one of the most relevant and important today. Its implications cover numerous fields and its impact can be felt in different aspects of our lives. From A-77636, through A-77636, to A-77636, this topic arouses interest and controversy in equal measure. In this article, we will analyze in detail the different facets of A-77636 and its influence on today's society. From its origins to its evolution in the present, we will explore every relevant aspect of A-77636 to understand its importance and possible ramifications in the future.
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Names | |
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Preferred IUPAC name
(1R,3S)-3-(Adamantan-1-yl)-1-(aminomethyl)-1H-2-benzopyran-5,6-diol | |
Identifiers | |
3D model (JSmol)
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ChEMBL | |
ChemSpider | |
PubChem CID
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UNII | |
CompTox Dashboard (EPA)
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Properties | |
C20H27NO3 | |
Molar mass | 329.440 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
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A-77636 is a synthetic drug which acts as a selective D1 receptor full agonist.[1] It has nootropic, anorectic, rewarding and antiparkinsonian effects in animal studies,[2][3][4][5][6] but its high potency and long duration of action causes D1 receptor downregulation and tachyphylaxis,[7][8][9] and unlike other D1 full agonists such as SKF-82,958, it does not produce place preference in animals.[10] A-77636 partially substituted for cocaine in animal studies, and has been suggested for use as a possible substitute drug in treating addiction,[11] but it is better known for its use in studying the role of D1 receptors in the brain.[12][13][14]