RDS-127

The following article will explore the impact of RDS-127 on contemporary society. RDS-127 has been a topic of interest and debate over the years, generating conflicting opinions among experts and the general public. This figure/person/theme has left an indelible mark on popular culture, politics, economics, and many other aspects of modern society. Through a detailed analysis we will try to shed light on the influence of RDS-127 in different areas, as well as examine its relevance in the current context. Various perspectives will be addressed and arguments will be presented that invite reflection and debate on this topic.

RDS-127
Structural formula of RDS-127
Ball-and-stick model of the RDS-127 molecule
Clinical data
ATC code
  • none
Identifiers
  • 4,7-dimethoxy-N,N-dipropyl-2,3-dihydro-1H-inden-2-amine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H27NO2
Molar mass277.408 g·mol−1
3D model (JSmol)
  • CCCN(CCC)C1CC2=C(C=CC(=C2C1)OC)OC
  • InChI=1S/C17H27NO2/c1-5-9-18(10-6-2)13-11-14-15(12-13)17(20-4)8-7-16(14)19-3/h7-8,13H,5-6,9-12H2,1-4H3 ☒N
  • Key:FPAHQTSJKYIURQ-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

RDS-127 is a drug which is used in scientific research. It acts as a D2-like receptor agonist[1] and also has some serotonin and adrenergic agonist effects,[2][3][4][5] as well as some anticholinergic action,[6][7] and produces both anorectic and pro-sexual effects in animal studies.[8][9]

See also

References

  1. ^ Arnerić SP, Long JP, Williams M, et al. (January 1983). "RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane): central effects of a new dopamine receptor agonist". The Journal of Pharmacology and Experimental Therapeutics. 224 (1): 161–70. PMID 6401334.
  2. ^ Arnerić SP, Roetker A, Long JP, Mott J, Barfknecht CF (June 1982). "Effects of semirigid methoxamine analogs on vascular smooth muscle: studies of methoxy-2-aminotetralin and 2-aminoindane derivatives". Archives Internationales de Pharmacodynamie et de Thérapie. 257 (2): 263–73. PMID 7114973.
  3. ^ Arnerić SP, Long JP (May 1984). "Evidence that a novel dopamine receptor agonist, RDS-127 has some centrally mediated cardiovascular actions". The Journal of Pharmacy and Pharmacology. 36 (5): 318–21. doi:10.1111/j.2042-7158.1984.tb04382.x. PMID 6145768. S2CID 24354158.
  4. ^ Clark JT, Smith ER (1986). "Failure of pimozide and metergoline to antagonize the RDS-127-induced facilitation of ejaculatory behavior". Physiology & Behavior. 37 (1): 47–52. doi:10.1016/0031-9384(86)90382-3. PMID 3737722. S2CID 24423685.
  5. ^ Rezaki YE, Ilhan M (1991). "Evaluation of alpha-adrenoceptor agonistic activity of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in rabbit and rat aortae". Archives Internationales de Pharmacodynamie et de Thérapie. 310: 76–86. PMID 1685313.
  6. ^ Sahin I, Ilhan M (1988). "The antimuscarinic activity of a dopamine receptor agonist (RDS-127) differentiates M2-muscarinic receptors of heart, ileum and trachea in guinea-pig". Archives Internationales de Pharmacodynamie et de Thérapie. 296: 163–72. PMID 2907277.
  7. ^ Sahin I, Tuncer M, Ilhan M (March 1990). "Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice". Archives Internationales de Physiologie et de Biochimie. 98 (1): 7–9. doi:10.3109/13813459009115730. PMID 1692697.
  8. ^ Arnerić SP, Roetker A, Long JP (September 1982). "Potent anorexic-like effects of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in the rat: a comparison with other dopamine-receptor agonists". Neuropharmacology. 21 (9): 885–90. doi:10.1016/0028-3908(82)90080-6. PMID 6897285. S2CID 12005863.
  9. ^ Kwong LL, Smith ER, Davidson JM, Peroutka SJ (October 1986). "Differential interactions of "prosexual" drugs with 5-hydroxytryptamine1A and alpha 2-adrenergic receptors". Behavioral Neuroscience. 100 (5): 664–8. doi:10.1037/0735-7044.100.5.664. PMID 2877677.
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