Nooglutyl

Nowadays, Nooglutyl has become a highly relevant topic in modern society. Attention has been focused on this issue due to its impact in various areas, from politics to popular culture. As Nooglutyl continues to be the subject of debate and discussion, it is crucial to analyze in detail its implications and repercussions on our daily lives. In this article, we will explore the many facets of Nooglutyl, examining its influence in different areas and its evolution over time. Likewise, we will address the different approaches and positions adopted by experts and opinion leaders regarding this issue, in order to offer a comprehensive and objective vision.

Nooglutyl
Names
IUPAC name
N--L-glutamic acid
Systematic IUPAC name
(2S)-2-(5-Hydroxypyridine-3-carboxamido)pentanoic acid
Other names
Nooglutil
Identifiers
3D model (JSmol)
ChemSpider
UNII
  • InChI=1S/C11H12N2O6/c14-7-3-6(4-12-5-7)10(17)13-8(11(18)19)1-2-9(15)16/h3-5,8,14H,1-2H2,(H,13,17)(H,15,16)(H,18,19)/t8-/m0/s1
    Key: XFZGYOJFPGPYCS-QMMMGPOBSA-N
  • InChI=1/C11H12N2O6/c14-7-3-6(4-12-5-7)10(17)13-8(11(18)19)1-2-9(15)16/h3-5,8,14H,1-2H2,(H,13,17)(H,15,16)(H,18,19)/t8-/m0/s1
    Key: XFZGYOJFPGPYCS-QMMMGPOBBD
  • O=C(c1cncc(O)c1)N(C(=O)O)CCC(=O)O
Properties
C11H12N2O6
Molar mass 268.225 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).

Nooglutyl is a nootropic agent that was studied at the Research Institute of Pharmacology, Russian Academy of Medical Sciences as a potential treatment for amnesia.[1]

In animal models, it has a variety of central nervous system effects.[2][3][4][5]

Nooglutyl has some structural similarities to Picamilon (N-Nicotinoyl-GABA). Nooglutyl is N-5-HydroxyNicotinoyl-L-Glutamic acid.

References

  1. ^ Flekhter, Oxana B. (2000). "Nooglutil, Russian Academy of Medical Science". Current Opinion in Central & Peripheral Nervous System Investigational Drugs. 2 (4): 491–497.
  2. ^ V. V. Yasnetsov; V. A. Pravdivtsev; V. M. Popov; T. A. Voronina; N. M. Kiseleva; S. B. Kozlov (May 1995). "Antimotion Effect of Nooglutyl and Its Neuronal Mechanism". Bulletin of Experimental Biology and Medicine. 119 (5): 515–516. doi:10.1007/BF02543440. PMID 7579248. S2CID 6344628.
  3. ^ Voronina, TA; Borlikova, GG; Garibova, TL; Proskuryakova, TV; Petrichenko, OB; Burd, SG; Avakyan, GN (2002). "Effect of nooglutil on benzodiazepine withdrawal syndrome and binding of 3H-spiperone with D2 receptors in rat striatum". Bulletin of Experimental Biology and Medicine. 134 (5): 448–50. doi:10.1023/a:1022634112815. PMID 12802448. S2CID 142803.
  4. ^ Garibova, TL; Galaeva, IP; Voronina, TA; Kraĭneva, VA; Kapitsa, IG; Kirichenko, SV; Makarenko, AN; Mirzoian, GR; Kuznetsova, EA (2003). "Effect of nooglutil on rats with intracerebral posttraumatic hematoma (hemorrhagic stroke)". Eksperimental'naia i Klinicheskaia Farmakologiia. 66 (3): 13–6. PMID 12924225.
  5. ^ Povarova, OV; Garibova, TL; Kalenikova, EI; Galaeva, IP; Kraĭneva, VA; Medvedev, OS; Voronina, TA (2004). "Effect of phenyl-tert-butylnitrone, mexidol and nooglutil on the ischemic lesion zone and memory in rats following middle cerebral artery occlusion". Eksperimental'naia i Klinicheskaia Farmakologiia. 67 (1): 3–6. PMID 15079898.


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