L-745,870

In this article, we will explore the fascinating world of L-745,870 and its many facets. L-745,870 is a topic that has captured the attention and interest of many people throughout history, being the object of study, debate and reflection in various disciplines. From its origins to the present, L-745,870 has been a relevant topic that has sparked the interest of experts and fans alike. Throughout these pages, we will analyze its impact on society, its evolution over time, and the different perspectives that exist around L-745,870. This article aims to offer a comprehensive and enriching vision about L-745,870, generating a space for reflection and learning for all readers interested in this exciting topic.

L-745,870
Identifiers
  • 3-(methyl)-1H-pyrrolopyridine
CAS Number
PubChem CID
IUPHAR/BPS
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC18H19ClN4
Molar mass326.83 g·mol−1
3D model (JSmol)
  • c1cc2c(cc2nc1)CN3CCN(CC3)c4ccc(cc4)Cl
  • InChI=1S/C18H19ClN4/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18/h1-7,12H,8-11,13H2,(H,20,21) ☒N
  • Key:OGJGQVFWEPNYSB-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

L-745,870 is a drug which acts as a dopamine receptor antagonist selective for the D4 subtype, and has antipsychotic effects in animal models, though it was not effective in human trials.[1][2][3]

References

  1. ^ Bristow LJ, Kramer MS, Kulagowski J, Patel S, Ragan CI, Seabrook GR (June 1997). "Schizophrenia and L-745,870, a novel dopamine D4 receptor antagonist". Trends in Pharmacological Sciences. 18 (6): 186–8. doi:10.1016/s0165-6147(97)01066-3. PMID 9226994.
  2. ^ Zhang K, Grady CJ, Tsapakis EM, Andersen SL, Tarazi FI, Baldessarini RJ (September 2004). "Regulation of working memory by dopamine D4 receptor in rats". Neuropsychopharmacology. 29 (9): 1648–55. doi:10.1038/sj.npp.1300491. PMID 15138447.
  3. ^ Moustgaard A, Hau J, Lind NM (2008). "Effects of dopamine D4 receptor antagonist on spontaneous alternation in rats". Behavioral and Brain Functions. 4: 49. doi:10.1186/1744-9081-4-49. PMC 2577092. PMID 18945334.


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