In today's world, Ansofaxine has become a topic of great interest and relevance. The impact of Ansofaxine is becoming increasingly evident in multiple areas of life, from technology to politics, culture and society in general. In this article, we will explore the different facets of Ansofaxine and its influence on various aspects of our daily reality. From its origins to its current evolution, we will analyze how Ansofaxine has been shaping the world we live in and how it continues to do so in the future. Through in-depth analysis and critical reflection, we aim to shed light on the importance and relevance of Ansofaxine today.
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Clinical data | |
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Other names | LY03005; LPM570065; 4-Methylbenzoate desvenlafaxine |
Routes of administration | By mouth |
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Chemical and physical data | |
Formula | C24H31NO3 |
Molar mass | 381.516 g·mol−1 |
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Toludesvenlafaxine, also formerly known as ansofaxine and sold under the brand name Ruoxinlin, is an antidepressant which is approved for the treatment of major depressive disorder in China.[1] It is also under development for use in other countries like the United States.[1] It is a serotonin–norepinephrine–dopamine reuptake inhibitor (SNDRI) and was developed by Luye Pharma Group.[1][2][3][4]
Toludesvenlafaxine is described as an SNDRI and prodrug to desvenlafaxine.[2] However, unlike desvenlafaxine, which has in vitro IC50 values of 53 nM and 538 nM for inhibition of serotonin and norepinephrine reuptake, respectively, toludesvenlafaxine has respective in vitro IC50 values of 723 nM, 763 nM, and 491 nM for serotonin, norepinephrine, and dopamine reuptake inhibition.[2] As such, toludesvenlafaxine appears to be a more balanced reuptake inhibitor of serotonin, norepinephrine, and dopamine than desvenlafaxine.[2]
As of July 2018, toludesvenlafaxine is in preregistration for the treatment of depression in the United States, the European Union, and Japan.[1] As of January 2023, it is also in phase 3 clinical trials for the treatment of generalized anxiety disorder.[1] In March 2020, the United States Food and Drug Administration accepted Luye Pharma's New Drug Application for toludesvenlafaxine, which remains under review.[1][5] In November 2022, toludesvenlafaxine was approved for the treatment of depression in China under the brand name Ruoxinlin.[6][7]