Daledalin
In today's world, Daledalin has become a topic of utmost importance and interest to a wide range of people. Whether due to its impact on society, its relevance in the scientific field or its influence on economic development, Daledalin has managed to capture the attention and debate of experts, professionals and citizens around the world. Throughout history, Daledalin has played a crucial role in the evolution of different aspects of human life, and its study and understanding are essential to address the challenges and opportunities that arise today. In this article, we will explore in depth the impact, importance and implications of Daledalin, analyzing its different facets and offering a global view of its relevance in the contemporary world.
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| Formula | C19H24N2 |
| Molar mass | 280.415 g·mol−1 |
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Daledalin (UK-3557-15) is an antidepressant which was synthesized and trialed for depression in the early 1970s, but was never marketed.[1][2][3] It is a selective norepinephrine reuptake inhibitor, with no significant effects on the reuptake of serotonin and dopamine, and no antihistamine or anticholinergic properties.[2][4]
Synthesis
Daledalin can be prepared by the reduction of amedalin with diborane.[2]
Daledalin synthesis
References
- ^ Triggle DJ (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 978-0-412-46630-4.
- ^ a b c Cañas-Rodriguez A, Leeming PR (July 1972). "N-Phenyl-2-indolinones and N-phenylindolines. A new class of antidepressant agents". Journal of Medicinal Chemistry. 15 (7): 762–70. doi:10.1021/jm00277a017. PMID 5043876.
- ^ Edwards JG, Ollerenshaw DP (1974). "Daledalin tosylate: a controlled trial in depressive illness". Current Medical Research and Opinion. 2 (6): 305–12. doi:10.1185/03007997409114763. PMID 4614944.
- ^ Koe BK (December 1976). "Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain". Journal of Pharmacology and Experimental Therapeutics. 199 (3): 649–661. PMID 994022.
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