Paramethasone

Today, we want to delve into the exciting world of Paramethasone. Whether we are talking about the history of Paramethasone, its impact on society today, or its possible applications in the future, Paramethasone is a topic that never ceases to amaze us. Throughout this article, we will explore the different aspects of Paramethasone, from its origins to its implications in daily life. Regardless of whether you are an expert on the subject or are just discovering its existence, we invite you to immerse yourself in this fascinating universe and discover everything that Paramethasone has to offer us.

Chemical compound

Not to be confused with Paramethadione.

Paramethasone

Clinical data
Other names	(6S,8S,9S,10R,11S,13S,14S,16R,17R)-6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopentaphenanthren-3-one
AHFS/Drugs.com	International Drug Names
ATC code	H02AB05 (WHO)
Identifiers
IUPAC name (6α,11β,16α)-6-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
CAS Number	53-33-8 Y
PubChem CID	5875
DrugBank	DB01384 N
ChemSpider	5664 Y
UNII	VFC6ZX3584
KEGG	C07413 N
ChEMBL	ChEMBL1579 Y
CompTox Dashboard (EPA)	DTXSID3023421
ECHA InfoCard	100.000.155
Chemical and physical data
Formula	C22H29FO5
Molar mass	392.467 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C\1\C=C/4(/C(=C/1)(F)C24(O)C3((O)(C(=O)CO)(C23)C)C)C
InChI InChI=1S/C22H29FO5/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-20(15,2)19(13)17(26)9-21(14,3)22(11,28)18(27)10-24/h4-5,7,11,13-14,16-17,19,24,26,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20+,21+,22+/m1/s1 Y Key:MKPDWECBUAZOHP-AFYJWTTESA-N Y
NY (what is this?)  (verify)

Paramethasone is a fluorinated glucocorticoid with anti-inflammatory and immunosuppressant properties.

References

1. ^ Toxnet: Paramethasone Archived 2019-08-29 at the Wayback Machine

Further reading

• Wershil BK, Furuta GT, Lavigne JA, Choudhury AR, Wang ZS, Galli SJ (1995). "Dexamethasone and cyclosporin A suppress mast cell-leukocyte cytokine cascades by multiple mechanisms". International Archives of Allergy and Immunology. 107 (1–3): 323–4. doi:10.1159/000237015. PMID 7613160.
• Riccardi C, Cifone MG, Migliorati G (December 1999). "Glucocorticoid hormone-induced modulation of gene expression and regulation of T-cell death: role of GITR and GILZ, two dexamethasone-induced genes". Cell Death and Differentiation. 6 (12): 1182–9. doi:10.1038/sj.cdd.4400609. PMID 10637434.
• Lavista Llanos S, Roldán A (April 1999). "Effect of dexamethasone on nitric oxide (NO.) production by cultured astrocytes". Biocell. 23 (1): 29–35. PMID 10904533.

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