In the contemporary world, JWH-019 plays a fundamental role in today's society. Whether on a personal, social, political or economic level, JWH-019 has acquired undeniable relevance in our lives. From its origins to the present, JWH-019 has been the subject of debate, analysis and reflection in various areas, generating opinion and controversy. In this article, we will delve into the impact and importance of JWH-019 in the current context, exploring its implications and opening the debate on its relevance in contemporary society.
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Formula | C25H25NO |
Molar mass | 355.481 g·mol−1 |
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JWH-019 is an analgesic chemical from the naphthoylindole family that acts as a cannabinoid agonist at both the CB1 and CB2 receptors. It is the N-hexyl homolog of the more common synthetic cannabinoid compound JWH-018. Unlike the butyl homolog JWH-073, which is several times weaker than JWH-018, the hexyl homolog is only slightly less potent, although extending the chain one carbon longer to the heptyl homolog JWH-020 results in dramatic loss of activity. These results show that the optimum side chain length for CB1 binding in the naphthoylindole series is the five-carbon pentyl chain, shorter than in the classical cannabinoids where a seven-carbon heptyl chain produces the most potent compounds. This difference is thought to reflect a slightly different binding conformation adopted by the naphthoylindole compounds as compared to the classical cannabinoids, and may be useful in characterizing the active site of the CB1 and CB2 receptors.
As of October 2015 JWH-019 is a controlled substance in China.
In Poland, JWH-019 is I-N (Poland).
JWH-019 is illegal in Sweden.
JWH-019 is Class B in the United Kingdom.
JWH-019 is a Schedule I controlled substance, controlled federally in the United States.