In today's article, we are going to explore the topic of Wogonin in depth. From its origins to its relevance today, we will dive into every key aspect related to Wogonin. We will analyze its impact on society, culture and the economy, as well as its role in the lives of people in different parts of the world. Through this detailed exploration, we hope to shed light on the lesser-known aspects of Wogonin and provide a comprehensive view of its importance in today's world.
![]() | |
![]() | |
Names | |
---|---|
IUPAC name
5,7-Dihydroxy-8-methoxyflavone
| |
Systematic IUPAC name
5,7-Dihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one | |
Other names
Vogonin
Norwogonin 8-methyl ether | |
Identifiers | |
3D model (JSmol)
|
|
ChEBI | |
ChEMBL | |
ChemSpider | |
KEGG | |
PubChem CID
|
|
UNII | |
CompTox Dashboard (EPA)
|
|
| |
| |
Properties | |
C16H12O5 | |
Molar mass | 284.267 g·mol−1 |
Melting point | 203 to 206 °C (397 to 403 °F; 476 to 479 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C , 100 kPa).
|
Wogonin is an O-methylated flavone, a flavonoid-like chemical compound which is found in Scutellaria baicalensis.
The glycosides of wogonin are known as wogonosides. For example, oroxindin is a wogonin glucuronide isolated from Oroxylum indicum. It is one of the active ingredients of Sho-Saiko-To, a Japanese herbal supplement.
Wogonin has been found in one study to have anxiolytic properties in mice at doses of 7.5 to 30 mg/kg, without exhibiting the sedative and muscle-relaxing properties of benzodiazepines. Preliminary in vitro studies have shown pharmacological effects that indicate wogonin may have anti-tumor properties. Wogonin has also been found to possess anticonvulsant effects. It acts as a positive allosteric modulator of the benzodiazepine site of the GABAA receptor with an binding affinity of Ki 0.92μM and an IC50 value of 1.26μM which is about 100x less potent than diazepam (IC50 value of 0.012μM). The LD50 of pure Wogonin in mice is 3.9 grams per kilogram of body weight suggesting low toxicity