IFNA8

In the modern world, IFNA8 has gained great interest and relevance in different areas of society. With the advancement of technology and globalization, IFNA8 has become a constant topic of conversation, ranging from cultural and artistic to scientific and political aspects. The influence of IFNA8 has spread worldwide, generating debates and conflicting opinions in public opinion. In this article, we will explore different perspectives and approaches around IFNA8, to better understand its impact on our daily lives and in the future.

Protein-coding gene in the species Homo sapiens

IFNA8
Identifiers
Aliases	IFNA8, IFN-alphaB, interferon alpha 8
External IDs	OMIM: 147568; MGI: 2667155; HomoloGene: 68237; GeneCards: IFNA8; OMA:IFNA8 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9p21.3 Start 21,409,117 bp End 21,410,185 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 C4|4 42.02 cM Start 88,561,878 bp End 88,562,696 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar cortex cerebellar hemisphere right hemisphere of cerebellum primary visual cortex prefrontal cortex Top expressed in embryo embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity type I interferon receptor binding cytokine receptor binding Cellular component extracellular region extracellular space Biological process natural killer cell activation involved in immune response B cell differentiation defense response B cell proliferation blood coagulation positive regulation of peptidyl-serine phosphorylation of STAT protein humoral immune response adaptive immune response defense response to virus type I interferon signaling pathway response to exogenous dsRNA T cell activation involved in immune response innate immune response cytokine-mediated signaling pathway regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3445 230396 Ensembl ENSG00000120242 ENSMUSG00000063376 UniProt P32881 Q80SU4 RefSeq (mRNA) NM_002170 NM_177347 RefSeq (protein) NP_002161 NP_796321 Location (UCSC) Chr 9: 21.41 – 21.41 Mb Chr 4: 88.56 – 88.56 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Interferon alpha-8 is a protein that in humans is encoded by the IFNA8 gene.

References

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000120242 – Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000063376 – Ensembl, May 2017
3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. ^ Olopade OI, Bohlander SK, Pomykala H, Maltepe E, Van Melle E, Le Beau MM, Diaz MO (Dec 1992). "Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasia". Genomics. 14 (2): 437–43. doi:10.1016/S0888-7543(05)80238-1. PMID 1385305.
6. ^ "Entrez Gene: IFNA8 interferon, alpha 8".

Further reading

• Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes". J. Mol. Biol. 185 (2): 227–60. doi:10.1016/0022-2836(85)90401-2. PMID 4057246.
• Goeddel DV, Leung DW, Dull TJ, et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs". Nature. 290 (5801): 20–6. Bibcode:1981Natur.290...20G. doi:10.1038/290020a0. PMID 6163083. S2CID 1900300.
• Yelverton E, Leung D, Weck P, et al. (1981). "Bacterial synthesis of a novel human leukocyte interferon". Nucleic Acids Res. 9 (3): 731–41. doi:10.1093/nar/9.3.731. PMC 327233. PMID 6164048.
• Bowden DW, Mao J, Gill T, et al. (1984). "Cloning of eukaryotic genes in single-strand phage vectors: the human interferon genes". Gene. 27 (1): 87–99. doi:10.1016/0378-1119(84)90241-5. PMID 6325303.
• Tiefenbrun N, Melamed D, Levy N, et al. (1996). "Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest". Mol. Cell. Biol. 16 (7): 3934–44. doi:10.1128/MCB.16.7.3934. PMC 231390. PMID 8668211.
• Hussain M, Gill DS, Liao MJ, Testa D (1997). "Interferon-alpha 8b is the only variant of interferon-alpha 8 identified in a large human population". J. Interferon Cytokine Res. 16 (7): 523–9. doi:10.1089/jir.1996.16.523. PMID 8836918.
• Nyman TA, Tölö H, Parkkinen J, Kalkkinen N (1998). "Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes". Biochem. J. 329. ( Pt 2) (2): 295–302. doi:10.1042/bj3290295. PMC 1219044. PMID 9425112.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hardy MP, Owczarek CM, Jermiin LS, et al. (2005). "Characterization of the type I interferon locus and identification of novel genes". Genomics. 84 (2): 331–45. doi:10.1016/j.ygeno.2004.03.003. PMID 15233997.

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